B
Bishadi
Guest
Research to share the non-canonical interface of proteins within a living form.
In current science the intent of proteins to associate is chemically described in metabolic pathways or processes such as catabolism for the cellular respiration.
This shares a chemically described form of metabolic processes.
This thread is to share something; that living structures are not combining mass for ‘ionic’ exchange for the usage of energy as prescribed in chemistry but that the potential being used is the energy released upon the reaction; ‘light’.
A non-canonical or non-conforming insight has been observed per this publication.
Science 29 February 2008:
Vol. 319. no. 5867, pp. 1232 - 1235
DOI: 10.1126/science.1153445
Deeply Inverted Electron-Hole Recombination in a Luminescent
Antibody-Stilbene Complex
Erik W. Debler,1,2* Gunnar F. Kaufmann,2,3,4 Michael M. Meijler,2,3 Andreas Heine,1
Jenny M. Mee,2,3 Goran Pljevalj i ,1 Angel J. Di Bilio,5 Peter G. Schultz,2,3 David P. Millar,1
Kim D. Janda,2,3,4,6 Ian A. Wilson,1,2 Harry B. Gray,5 Richard A. Lerner1,2,3
The blue-emissive antibody EP2-19G2 that has been elicited against trans-stilbene has unprecedented ability to produce bright luminescence and has been used as a biosensor in various applications. We show that the prolonged luminescence is not stilbene fluorescence. Instead, the emissive species is a charge transfer excited complex of an anionic stilbene and a cationic, parallel -stacked tryptophan. Upon charge recombination, this complex generates exceptionally bright blue light. Complex formation is enabled by a deeply penetrating ligand-binding pocket, which in turn results from a noncanonical interface between the two variable domains of the antibody.
What this is sharing is that a ‘rule breaking’ (non-canonical) occurrence has been identified. IN which structures ‘anionic stilbene’ and tryptophan (stacked) reacts upon combining and releases a ‘exceptionally bright blue light’…….
I will bet the combining of the 2 potentials represents a ‘golden ratio’ of increased potential; a latter effect.
i.e…. put your ear to a conch shell; notice the increased potential. Not magic; entangled energy to the structure/environment.